Advantages of the umbilical cord

Comparison of Cord Blood (HSC) & Cord Stem Cell (MSC)

Hematopoietic Stem Cell (HSC) Mesenchymal Stem Cell (MSC)
Indications
  • Malignancies
  • Hemoglobinopathies & Blood disorders
  • Metabolic Disease
  • Autoimmune disease
  • Cell therapy
  • Tissue engineering
  • Regenerative medicine
HLA Typing HLA Typing 4/6 Allogeneic transplantation without HLA typing, will not induce the immune reaction of lymphocyte.
Graft Versus Host Disease (GVHD) Problems may last for a long time after HSCT. promote engraftment of CD34+ & suppress GVHD
Stem cell expansion Need technical breakthrough (adult require double units for transplantation) Can be expanded

Comparison of the Source of Stem Cell

Item Umbilical Cord Umbilical Cord blood Bone marrow
Collection process Non-invasive, Collection is simple Non-invasive, Collection is simple invasive, collection is difficult
HLA Typing and immunological  rejection of receiver No strict HLA typing is needed, immunological  rejection rate is low More strict HLA typing is needed, immunological  rejection rate is high The strictest HLA typing is needed, immunological  rejection is the highest
Age of cell 0 year old 0 year old Same age as the donor
Quantity (concentration) of MSC Highest Lower Lower